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Updated: Feb 14, 2026

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Structure Determination and Characterization of a Family of Primary Alcohol Solvates
Kalyan V Vasudevan1, Matthew L Peterson1
1Pharmaceutical Sciences, Engineering & Technology, Biogen, Cambridge, Massachusetts 02142.
Abstract:
We report the preparation and structural characterization of a family of primary alcohol solvates of a small-molecule hydrochloride salt. The structures of the solvates are probed by powder and single crystal X-ray diffraction, and the compounds were additionally characterized by polarized light microscopy, thermogravimetric analysis, and dynamic scanning calorimetry. A comparison of the lattices of each compound is also provided. The results demonstrate the existence of a common solvating channel and highlight the importance of understanding the form landscape early in the development process.
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