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Liver-specific deletion of TSHR inhibits hepatic lipid accumulation in mice

Lingyan Zhou1, Kunpeng Wu2, Liya Zhang3

  • 1Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong University, Jinan, Shandong, 250021, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, 250021, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, 250021, China; Department of Endocrinology and Metabolism, The Second Hospital of Shandong University, Jinan, Shandong, 250033, China.

Biochemical and Biophysical Research Communications
|February 9, 2018
PubMed

Insights

Thyroid-stimulating hormone receptor (TSHR) in the liver impacts lipid metabolism, reducing hepatic and serum lipids. However, liver TSHR absence does not affect overall systemic energy metabolism.

Area of Science:

  • Endocrinology
  • Metabolic Research
  • Molecular Biology

Background:

  • The role of the thyroid-stimulating hormone receptor (TSHR) in liver lipid accumulation is not fully understood.
  • While TSHR in the thyroid is well-studied, its function in liver lipid metabolism and systemic energy balance remains largely uninvestigated.

Purpose of the Study:

  • To investigate the effect of hepatic TSHR absence on liver lipid metabolism and systemic energy balance.
  • To elucidate the specific role of TSHR in regulating hepatic lipid synthesis and catabolism.

Main Methods:

  • Generation of hepatic TSHR conditional knockout (LT-KO) mice using Cre/LoxP technology.
  • Analysis of hepatic triglyceride and cholesterol content.
  • Measurement of serum lipid profiles, including LDL-C levels.
  • Assessment of systemic energy metabolism using metabolic chambers.

Main Results:

  • Liver-specific TSHR knockout (LT-KO) mice showed reduced hepatic triglyceride and cholesterol levels.
  • LT-KO mice exhibited decreased serum lipids, particularly LDL-C.
  • Despite altered liver lipid metabolism, hepatic TSHR deletion did not impact systemic energy metabolism.

Conclusions:

  • Hepatic TSHR plays a significant role in regulating liver lipid metabolism.
  • TSHR in the liver influences lipid synthesis and catabolism, affecting both hepatic and serum lipid levels.
  • Unlike its thyroidal role, hepatic TSHR has minimal impact on whole-body energy metabolism.
Keywords:
Energy metabolismHepatic lipid accumulationTSHR

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