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Cyclosporine and the immune response: basic aspects.

A D Hess, P M Colombani, A H Esa

    Critical Reviews in Immunology
    |January 1, 1986
    PubMed
    Summary
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    Cyclosporine (CsA) promotes transplantation tolerance by selectively impacting T lymphocyte populations. It inhibits interleukin-2 while sparing suppressor T cells, suggesting complex immune modulation.

    Area of Science:

    • Immunology
    • Pharmacology

    Background:

    • Cyclosporine (CsA) is a crucial immunosuppressant for preventing organ transplant rejection and graft-vs.-host disease.
    • CsA has demonstrated the ability to induce transplantation tolerance in various animal models.
    • The mechanism of CsA's immunosuppression is linked to its effects on T lymphocyte populations.

    Purpose of the Study:

    • To investigate the selective effects of Cyclosporine on different T lymphocyte subsets.
    • To elucidate the role of interleukin-2 (IL-2) in CsA-mediated immunosuppression.
    • To explore the potential involvement of other factors in CsA's potentiation of suppressor T lymphocytes.

    Main Methods:

    • In vitro and in vivo studies were conducted to analyze T lymphocyte responses.
    • Assays were performed to measure interleukin-2 (IL-2) production and receptor expression.

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  • The impact of CsA on suppressor T cell induction and amplification was evaluated.

    • Main Results:

    • Cyclosporine (CsA) effectively inhibited interleukin-2 (IL-2) production and IL-2 receptor expression on cytotoxic T lymphocyte precursors.
    • CsA demonstrated a sparing effect on the induction of suppressor T cells.
    • Evidence suggests CsA facilitates suppressor T lymphocyte amplification independently of IL-2.

    Conclusions:

    • Cyclosporine (CsA) exhibits selective immunomodulatory effects, inhibiting helper and cytotoxic T cell responses while promoting suppressor T cell activity.
    • The findings indicate that factors beyond IL-2 are crucial for CsA's potentiation of suppressor T lymphocytes.
    • CsA serves as a valuable tool for dissecting intricate immune responses and cellular interactions in transplantation immunology.