Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human interleukin 1.

T Krakauer

    Critical Reviews in Immunology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Interleukin 1 (IL-1), a key immune mediator, enhances thymocyte responses and plays roles in inflammation. Researchers are clarifying its structure-function relationships due to recent purification advancements.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Staphylococcus aureus: the toxic presence of a pathogen extraordinaire.

    Current medicinal chemistry·2009
    Same author

    The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines.

    FEBS letters·2001
    Same author

    Serum cytokine levels and antibody response to influenza vaccine in the elderly.

    Immunopharmacology and immunotoxicology·2001
    Same author

    Suppression of endotoxin- and staphylococcal exotoxin-induced cytokines and chemokines by a phospholipase C inhibitor in human peripheral blood mononuclear cells.

    Clinical and diagnostic laboratory immunology·2001
    Same author

    Pentoxifylline inhibits ICAM-1 expression and chemokine production induced by proinflammatory cytokines in human pulmonary epithelial cells.

    Immunopharmacology·2000
    Same author

    Coordinate suppression of superantigen-induced cytokine production and T-cell proliferation by a small nonpeptidic inhibitor of class II major histocompatibility complex and CD4 interaction.

    Antimicrobial agents and chemotherapy·2000
    Same journal

    Leveraging Type I Interferons: Exploring Pathogenesis and Therapeutic Strategies in Autoimmune Diseases.

    Critical reviews in immunology·2026
    Same journal

    SLC2A1-Dependent Ketone Metabolism Regulates Tumor Progression and Immunotherapy Efficacy in Lung Adenocarcinoma.

    Critical reviews in immunology·2026
    Same journal

    Knockdown of IGF2BP2 Inhibits THBS1 in Regulating the Progression of Oral Squamous Cell Carcinoma: An Integrative Analysis.

    Critical reviews in immunology·2026
    Same journal

    Plasmodium Phosphatidylinositol 4-Kinase Beta (PI4Kβ): An Emerging Target at the Interface of Parasite Biology and Host Immunity.

    Critical reviews in immunology·2026
    Same journal

    Fusion Gene EPHB4-MET Driven by HOXA9 and Exerted Oncogenic Activity in Non-Small Cell Lung Cancer.

    Critical reviews in immunology·2026
    Same journal

    Secreted Phosphoprotein 1 Represents a Therapeutic Target that Promotes the Progression of Ovarian Cancer by Driving M2 Macrophage Infiltration.

    Critical reviews in immunology·2026
    See all related articles

    Area of Science:

    • Immunology
    • Molecular Biology
    • Biochemistry

    Background:

    • Interleukin 1 (IL-1) is a cytokine produced by monocytes/macrophages.
    • IL-1 enhances thymocyte responses to mitogens and is implicated in immunological and inflammatory reactions.
    • IL-1 is also identified as endogenous pyrogen, with its low production and activity complicating purification.

    Purpose of the Study:

    • To investigate the structure-function relationships of Interleukin 1 (IL-1).
    • To address whether the functional diversity of IL-1 stems from structural diversity or varied target-cell responses.
    • To leverage recent advancements in IL-1 purification and precursor molecule identification.

    Main Methods:

    • Purification of IL-1 components to homogeneity.
    • Obtaining a precursor molecule derived from a cloned cDNA sequence.

    Related Experiment Videos

  • Analyzing the biochemical properties and chemical structure of IL-1.

    • Main Results:

    • Human IL-1 activity is associated with multiple molecules of similar size but different compositions.
    • Advancements in purification have enabled detailed structural analysis.
    • A precursor molecule has been identified, aiding in understanding IL-1 synthesis.

    Conclusions:

    • The structural diversity of IL-1 components is being elucidated.
    • The relationship between IL-1 structure and its diverse biological functions can now be addressed.
    • Ongoing research is rapidly increasing knowledge of IL-1's chemical structure and biochemical properties.