Related Experiment Video
Updated: Feb 14, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Ocular surface squamous neoplasia in a setting of fungal keratitis: a rare co-occurrence
Swati Singh1, Ruchi Mittal2, Purvasha Narang3
1Ophthalmic Plastics, Orbit and Ocular Oncology Services, L J Eye Institute, Ambala, India. dr.swati888@yahoo.com.
Purpose:
To describe a rare co-occurrence of ocular surface squamous neoplasia (OSSN) in a patient with microbial keratitis.
Methods:
Case report.
Results:
We describe a 68-years female who developed ocular surface squamous neoplasia (OSSN) in an eye with culture proven severe fungal keratitis of 5 months duration, which progressed to endophthalmitis. She was managed with extended enucleation for left eye. Histopathology examination was consistent with squamous cell carcinoma of ocular surface with no corneal stromal/scleral/anterior chamber involvement. She received adjuvant chemotherapy with topical Interferon alpha2b (3 cycles) for positive margins. Six months after treatment, she is completely tumor free.
Conclusion:
Co-occurrence of OSSN and chronic fungal keratitis is rare. We recommend that patients with chronic ocular infections should be examined and followed closely for abnormally thickened limbal areas.
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