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2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition
Published on: December 26, 2016
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Cytokine gene polymorphism in denture stomatitis patients: A clinical study
A C Keşoğlu1, C Bural1, G E Genç2
1Department of Prosthodontics, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
Oral Diseases
|February 10, 2018
Summary
Cytokine gene variations in tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta (TGF-β), and interleukin-6 (IL-6) are linked to Candida growth in denture stomatitis patients. These findings offer insights into host defense mechanisms.
Area of Science:
- Oral microbiology and immunology
- Genetics and host-pathogen interactions
- Denture-related oral conditions
Background:
- Denture stomatitis (DS) is a common oral condition associated with Candida colonization.
- Cytokine gene polymorphisms may influence an individual's susceptibility and immune response to infections like DS.
- Understanding these genetic associations can inform targeted prevention and treatment strategies.
Purpose of the Study:
- To investigate the association between specific cytokine gene polymorphisms (TNF-α, TGF-β, IL-6, IL-10) and Candida colonization in patients with denture stomatitis.
- To compare Candida growth and genotype frequencies between healthy controls and DS patients.
Main Methods:
- Saliva and blood samples were collected from 160 complete denture wearers (80 healthy, 80 with DS).
- Mycological analysis determined salivary Candida counts.
- Gene polymorphism analysis identified genotypes for TNF-α, TGF-β, IL-6, and IL-10.
- Statistical analyses included t-tests, Mann-Whitney U, chi-square, and Yates correction.
Main Results:
- Significantly higher Candida albicans colony counts were observed in DS patients with the TNF-α GG genotype.
- Specific TGF-β haplotypes (TC GG, CC GG) showed differential distribution between DS and control groups.
- Candida glabrata colony counts were higher in DS patients with the IL-6 GG genotype.
- Distinct IL-6 genotype expression levels were noted across different types of denture stomatitis.
Conclusions:
- Specific genotypes of TNF-α, TGF-β, and IL-6 are significantly associated with denture stomatitis and Candida colonization.
- These genetic variations play a role in the host's defense mechanisms against DS.
- Further research into these cytokine gene polymorphisms could lead to novel therapeutic targets for DS management.
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