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[Progress on rheumatoid arthritis in elderly].

Xin Wang1, Qin Zhao1, Zhao-da Deng1

  • 1Department of Rheumatology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu, China.

Zhongguo Gu Shang = China Journal of Orthopaedics and Traumatology
|February 10, 2018
PubMed
Summary
This summary is machine-generated.

Elderly patients with rheumatoid arthritis require careful consideration of non-steroidal anti-inflammatory drugs (NSAIDs) and biological therapies due to increased infection risks. Traditional Chinese medicine, like Tripterygium wilfordii, shows promise for managing RA in older adults.

Keywords:
AgedRheumatoid arthritisTreatment

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Area of Science:

  • Rheumatology
  • Geriatric Medicine
  • Pharmacology

Background:

  • Elderly patients with rheumatoid arthritis (RA) face unique challenges, including higher risks of infection with biological therapies and comorbidities like cardiac and lung diseases.
  • Choosing appropriate treatments, such as non-steroidal anti-inflammatory drugs (NSAIDs), requires careful evaluation of individual risk factors in this population.
  • Current clinical studies often exclude older adults, leading to a gap in evidence-based medicine for geriatric RA management.

Purpose of the Study:

  • To review and highlight the specific considerations for treating elderly patients with rheumatoid arthritis.
  • To discuss the risks and benefits of various therapeutic options, including NSAIDs, biological therapies, and Traditional Chinese Medicine (TCM).
  • To emphasize the need for tailored treatment strategies that account for aging-related changes and comorbidities.

Main Methods:

  • Review of current literature on rheumatoid arthritis treatment in elderly populations.
  • Analysis of safety profiles for NSAIDs and biological therapies in older adults.
  • Exploration of the efficacy and safety of Traditional Chinese Medicine, specifically Tripterygium wilfordii, in geriatric RA.

Main Results:

  • Elderly RA patients are more susceptible to infections when using biological therapies.
  • Comorbidities common in older adults necessitate integrated treatment approaches.
  • Traditional Chinese Medicine, particularly Tripterygium wilfordii, demonstrates significant therapeutic effects and is being investigated in large clinical trials for geriatric RA.

Conclusions:

  • Treatment targets and standards for elderly RA patients differ from younger populations due to aging-related factors.
  • Further clinical studies are crucial to develop evidence-based guidelines for managing rheumatoid arthritis in the elderly.
  • Personalized treatment strategies considering comorbidities and specific risks are essential for effective geriatric RA care.