Protein coated gold nanoparticles as template for the directed synthesis of highly fluorescent gold nanoclusters
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Updated: Feb 14, 2026

Gold Nanoparticle Synthesis
Published on: July 10, 2021
1Chongqing Institutions of Higher Learning Center of Forensic Science Engineering and Research, Southwest University of Political Science and Law, Chongqing, 401120, People's Republic of China.
Abstract:
Bovine serum albumin (BSA) modified gold nanoparticles (AuNPs) was selected as template for the synthesis of AuNPs@gold nanoclusters (AuNCs) core/shell nanoparticles, in which BSA not only acted as dual functions agent for both anchoring and reducing Au3+ ions, but also was employed as a bridge between the AuNPs and AuNCs. Optical properties of AuNPs@AuNCs core/shell nanoparticles were studied using UV-visible and fluorescence spectroscopy. The prepared AuNPs@AuNCs core/shell nanoparticles exhibited sphere size uniformity with improved monodispersity, excellent fluorescence and fluorescent stability. Compared with AuNCs, AuNPs@AuNCs core/shell nanoparticles possessed large size and strong fluorescence intensity due to the effect of AuNPs as core. Moreover, the mechanism of the AuNPs induced fluorescence changes of the core/shell nanoparticles was first explored.
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