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Published on: February 16, 2020
Sulfonamidation of Aryl and Heteroaryl Halides through Photosensitized Nickel Catalysis
Taehoon Kim1, Stefan J McCarver2, Chulbom Lee1
1Department of Chemistry, Seoul National University, Seoul, 08826, South Korea.
Abstract:
Herein we report a highly efficient method for nickel-catalyzed C-N bond formation between sulfonamides and aryl electrophiles. This technology provides generic access to a broad range of N-aryl and N-heteroaryl sulfonamide motifs, which are widely represented in drug discovery. Initial mechanistic studies suggest an energy-transfer mechanism wherein C-N bond reductive elimination occurs from a triplet excited NiII complex. Late-stage sulfonamidation in the synthesis of a pharmacologically relevant structure is also demonstrated.
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