Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Enzymes02:34

Enzymes

95.5K
Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
95.5K
C4 Pathway and CAM01:27

C4 Pathway and CAM

49.4K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
49.4K
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

86.8K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
86.8K
Enzyme Kinetics01:19

Enzyme Kinetics

104.4K
Enzymes speed up reactions by lowering the activation energy of the reactants. The speed at which the enzyme turns reactants into products is called the rate of reaction. Several factors impact the rate of reaction, including the number of available reactants. Enzyme kinetics is the study of how an enzyme changes the rate of a reaction.
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
104.4K
Group Design02:01

Group Design

10.8K
The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between...
10.8K
What is Natural Selection?01:32

What is Natural Selection?

129.9K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
129.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioinformatic assessment of the potential amyloidogenicity of the human and evolutionarily more ancient proteomes.

The Biochemical journal·2026
Same author

Rapid antimicrobial susceptibility testing in bloodstream infections: current landscape and emerging technologies.

The Analyst·2026
Same author

Surface cues shape procoagulant properties of amyloidogenic microclots.

Cell death & disease·2026
Same author

Why Standard Tests Miss Spike-Induced Clot Alterations.

Blood advances·2026
Same author

Assessing the Health and Functionality of the Microcirculation Using Thermal Imaging.

Journal of biophotonics·2026
Same author

How far can you go? Extrapolating values of catalytic activity from known protein landscapes in natural and directed evolution.

Chemical Society reviews·2026
Same journal

3DICE: Interpretable 3D Cross-Modal Learning for Drug-Target Interaction Prediction and Large-Scale Drug Discovery.

Bioinformatics (Oxford, England)·2026
Same journal

KASSPer: Kinase Active Site Structure Prediction using Protein and Ligand Language Models and Its Application to Virtual Screening.

Bioinformatics (Oxford, England)·2026
Same journal

IDR searcher: a search engine solution for public image resources.

Bioinformatics (Oxford, England)·2026
Same journal

KCFtools: Rapid alignment-free method for introgression screening and GWAS using k-mer profiles.

Bioinformatics (Oxford, England)·2026
Same journal

Meta2DB: Curated shotgun metagenomic feature sets and metadata for health state prediction.

Bioinformatics (Oxford, England)·2026
Same journal

conMItion: an R package adjusting confounding factors for associations in multi-omics.

Bioinformatics (Oxford, England)·2026
See all related articles

Related Experiment Video

Updated: Feb 14, 2026

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.8K

Selenzyme: enzyme selection tool for pathway design.

Pablo Carbonell1, Jerry Wong1, Neil Swainston1

  • 1BBSRC/EPSRC Manchester Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology.

Bioinformatics (Oxford, England)
|February 10, 2018
PubMed
Summary
This summary is machine-generated.

Selenzyme is a free online tool that aids in selecting enzymes for metabolic pathway design. It simplifies the process of identifying suitable enzymes for creating valuable chemicals sustainably.

More Related Videos

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

18.5K
Bacterial Peptide Display for the Selection of Novel Biotinylating Enzymes
10:43

Bacterial Peptide Display for the Selection of Novel Biotinylating Enzymes

Published on: October 3, 2019

6.4K

Related Experiment Videos

Last Updated: Feb 14, 2026

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.8K
A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

18.5K
Bacterial Peptide Display for the Selection of Novel Biotinylating Enzymes
10:43

Bacterial Peptide Display for the Selection of Novel Biotinylating Enzymes

Published on: October 3, 2019

6.4K

Area of Science:

  • Synthetic biology
  • Metabolic engineering
  • Enzyme discovery

Background:

  • Designing biological systems requires selecting specific enzymes for desired chemical production.
  • Identifying optimal enzymes for metabolic pathways is a complex and critical step.

Purpose of the Study:

  • To introduce Selenzyme, a free online enzyme selection tool for metabolic pathway design.
  • To streamline the enzyme selection process for synthetic biology applications.

Main Methods:

  • Selenzyme guides users through decision steps to shortlist enzyme candidates.
  • The tool integrates data on sequence and reaction similarity, phylogenetic distance, and enzyme properties.
  • Key information includes sequence similarity, reaction catalysis, phylogenetic distance, multiple alignments, and predicted properties like solubility.

Main Results:

  • Selenzyme provides graphical representations of enzyme information.
  • It facilitates bespoke sequence selection for automated biofoundry workflows.
  • The tool aids in identifying suitable enzymes for producing valuable chemicals.

Conclusions:

  • Selenzyme simplifies enzyme selection for metabolic pathway design.
  • It supports the development of sustainable production of pharmaceuticals and biomaterials.
  • The tool is a valuable resource for synthetic biology research and biofoundries.