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Updated: Feb 14, 2026

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
Published on: December 19, 2014
The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans
Mansa A Munshi1, Justin M Gardin2, Ashutosh Singh3
1Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA.
Abstract:
Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans possesses a remarkable ability to disseminate through an immunocompromised host, making treatment difficult. Here, we examine the mechanism of survival of C. neoformans under varying host conditions and find a role for ceramide synthase in C. neoformans virulence. This study also provides a detailed lipidomics resource for the fungal lipid research community in addition to discovering a potential target for antifungal therapy.
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