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The association between oxidative stress and endothelial dysfunction in early childhood patients with Kawasaki

Takamichi Ishikawa1, Keigo Seki2

  • 1Department of Pediatrics, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan. ishikawa@hama-med.ac.jp.

BMC Cardiovascular Disorders
|February 11, 2018
PubMed

Insights

Oxidative stress is linked to endothelial dysfunction in children with Kawasaki disease (KD). Longer fever duration increases this risk, highlighting the importance of managing oxidative stress in pediatric KD patients.

Area of Science:

  • Pediatric Cardiology
  • Vascular Biology
  • Oxidative Stress Research

Background:

  • Oxidative stress is implicated in arteriosclerosis development in Kawasaki disease (KD).
  • Previous research has not specifically investigated this link in early childhood KD patients.
  • This study addresses the gap by examining oxidative stress and endothelial function in young KD patients.

Purpose of the Study:

  • To evaluate the association between oxidative stress markers and endothelial function in early childhood KD patients.
  • To compare oxidative stress levels and endothelial function in KD patients with and without coronary artery lesions (CAL) against healthy controls.
  • To identify factors contributing to endothelial dysfunction in pediatric KD.

Main Methods:

  • Prospective study comparing 50 children: 10 KD with CAL, 15 KD without CAL, and 25 healthy controls.
  • Measured derivatives of reactive oxygen metabolites (ROM) and flow-mediated dilatation (%FMD).
  • Analyzed biological characteristics and correlated ROM with %FMD, using multiple linear regression.

Main Results:

  • Significantly higher ROM levels and lower %FMD were observed in both KD groups compared to controls.
  • A strong negative correlation was found between ROM and %FMD (r = -0.60, p < 0.001).
  • ln-ROM and total fever duration were identified as significant determinants of %FMD in KD patients.

Conclusions:

  • Oxidative stress is strongly associated with endothelial dysfunction in early childhood KD.
  • Increased fever duration in KD patients correlates with a higher risk of oxidative stress-induced endothelial dysfunction.
  • Findings underscore the clinical relevance of oxidative stress and fever duration in managing pediatric KD vascular complications.
Abstract

Keywords:
ChildrenEndothelial dysfunctionKawasaki diseaseOxidative stressTotal fever duration

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