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Bone tissue aging affects mineralization of cement lines
Petar Milovanovic1, Annika Vom Scheidt2, Kathrin Mletzko2
1Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Lottestr. 55a, 22529 Hamburg, Germany; Laboratory for Anthropology and Skeletal Biology, Institute of Anatomy, Faculty of Medicine, University of Belgrade, Dr. Subotica 4/2, 11000 Belgrade, Serbia.
Bone
|February 11, 2018
Summary
Cement lines in bone are hypermineralized compared to osteons, with their mineralization increasing with tissue age. This finding is crucial for understanding bone strength and fracture resistance in aging and disease.
Area of Science:
- Bone biology
- Biomaterials science
- Skeletal biomechanics
Background:
- Cement lines, the boundaries of osteons, are thin (<5 μm) and their composition is debated.
- Osteonal and cement line mineralization are linked to bone tissue age and health.
Purpose of the Study:
- To investigate if cement lines are hypermineralized and if their mineralization degree correlates with osteon age.
- To analyze calcium content and mineralization patterns in cement lines and osteons.
Main Methods:
- Quantitative backscattered electron imaging (qBEI) to measure calcium content.
- Micro-Raman spectroscopy to assess phosphate and amide I peaks.
- Analysis of femoral cortical bone from postmenopausal women and bisphosphonate-treated individuals.
Main Results:
- Cement lines showed significantly higher calcium content than osteons (29.46 ± 0.80 vs. 26.62 ± 1.11 wt%).
- Cement lines had a higher phosphate/amide I ratio, indicating increased mineralization.
- A strong positive correlation was found between cement line and osteon mineralization, decreasing with higher osteonal mineralization.
Conclusions:
- Cement lines are hypermineralized and their mineralization degree is related to osteonal mineralization and tissue age.
- Understanding cement line mineralization is vital for predicting bone fracture resistance and understanding aging and disease effects.
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