Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Constraints and Statical Determinacy01:26

Constraints and Statical Determinacy

1.0K
In structural engineering, the equilibrium of a system is not only determined by its equations of equilibrium but also with the help of constraints. Constraints refer to restrictions on the motion of a system. The proper combinations of constraints can minimize the total number of constraints needed to maintain a system in mechanical equilibrium. When this happens, the system is said to be statically determinate. For such systems, the unknown reaction supports can be estimated using equilibrium...
1.0K
Survey Safety01:28

Survey Safety

421
Surveying near highways, rough terrain, or power lines involves significant risks. Working along highways is particularly dangerous and requires the use of warning signs and flagmen. It is safest to avoid working directly on roads and use offsets whenever possible. When highway work is unavoidable, it must follow all safety guidelines. Surveyors should wear bright clothing, such as orange reflective vests, to ensure visibility to motorists, coworkers, and hunters. In construction zones, wearing...
421
Household Wiring And Electrical Safety01:13

Household Wiring And Electrical Safety

1.7K
Companies that supply power to most modern households use three conductors, typically called a three-wire line. While one is neutral, the other two are both at 120 V but with opposite polarity, giving a voltage of 240 V between them. With a three-wire line, high-power appliances that require 240 V, such as electric stoves and clothes dryers, are linked between the two hot lines. 120 V appliances can be connected between the neutral and either of the hot lines. The neutral side, which is always...
1.7K
Optimal Foraging00:48

Optimal Foraging

14.0K
How animals obtain and eat their food is called foraging behavior. Foraging can include searching for plants and hunting for prey and depends on the species and environment.
14.0K
Optimization Problems01:26

Optimization Problems

85
Optimization problems often involve identifying maximum or minimum values under specific constraints. A well-known example is determining the longest horizontal pipe that can be moved around a right-angled corner, where a 3-meter-wide hallway meets a 2-meter-wide hallway. This scenario, common in architectural design and industrial transport, can be understood conceptually through geometric and trigonometric reasoning.To visualize the problem, consider the pipe as a straight line that touches...
85
Computed Tomography01:10

Computed Tomography

9.0K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
9.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomarkers for Alzheimer's disease and mild cognitive impairment: Recent advances in task-based EEG.

Journal of Alzheimer's disease : JAD·2026
Same author

Hemispherectomy in infants: an institutional experience with 21 patients.

Journal of neurosurgery. Pediatrics·2026
Same author

Human Neocortical Glutamatergic Neurons Revealed Through Multimodal Profiling.

bioRxiv : the preprint server for biology·2026
Same author

Personalization and network specificity of cerebellar TMS in schizophrenia.

medRxiv : the preprint server for health sciences·2026
Same author

Developmental relationships between the human alpha rhythm and intrinsic neural timescales are dependent on neural hierarchy.

Journal of neurophysiology·2025
Same author

New avenues for understanding what deep networks learn from EEG.

Frontiers in robotics and AI·2025
Same journal

Segmentation of the parasagittal dura mater on multi-center 3D-FLAIR MRI.

NeuroImage·2026
Same journal

Spatial frequency channels implement a mental ruler in spatial vision.

NeuroImage·2026
Same journal

Exploring the Link Between Intravoxel Incoherent Motion Measured Brain Diffusivity During Wakefulness and Sleep Macrostructure in the Elderly.

NeuroImage·2026
Same journal

Closed-loop adaptation of transcranial magnetic stimulation intensity with electroencephalography feedback.

NeuroImage·2026
Same journal

Volumetric postmortem MRI of the medial temporal lobe in Alzheimer's disease and related disorders: methodological advances and implications for in vivo biomarker development.

NeuroImage·2026
Same journal

Neural responses to equity and inequity when receiving vicarious rewards for self and charity during adolescence.

NeuroImage·2026
See all related articles

Related Experiment Video

Updated: Feb 14, 2026

Recording Human Electrocorticographic ECoG Signals for Neuroscientific Research and Real-time Functional Cortical Mapping
13:32

Recording Human Electrocorticographic ECoG Signals for Neuroscientific Research and Real-time Functional Cortical Mapping

Published on: June 26, 2012

26.9K

Computationally optimized ECoG stimulation with local safety constraints.

Seyhmus Guler1, Moritz Dannhauer2, Biel Roig-Solvas3

  • 1Computational Radiology Laboratory (CRL), Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

Neuroimage
|February 11, 2018
PubMed
Summary
This summary is machine-generated.

This study introduces an efficient method to prevent dangerous current density hotspots during electrocorticography (ECoG) stimulation, optimizing targeted brain modulation for future brain-computer interfaces.

Keywords:
ECoGElectrocorticography stimulationLocal safety constraintsOptimizationOptimizedSafety

More Related Videos

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
09:57

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index

Published on: January 2, 2012

28.6K
Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability
08:22

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability

Published on: October 7, 2017

8.6K

Related Experiment Videos

Last Updated: Feb 14, 2026

Recording Human Electrocorticographic ECoG Signals for Neuroscientific Research and Real-time Functional Cortical Mapping
13:32

Recording Human Electrocorticographic ECoG Signals for Neuroscientific Research and Real-time Functional Cortical Mapping

Published on: June 26, 2012

26.9K
How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
09:57

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index

Published on: January 2, 2012

28.6K
Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability
08:22

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability

Published on: October 7, 2017

8.6K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Computational Modeling

Background:

  • Direct cortical stimulation is crucial for mapping and modulating brain activity, with applications in brain-computer interfaces.
  • Electrocorticography (ECoG) stimulation uses dense electrode arrays but faces safety limits due to proximity, risking local current density 'hot-spots'.
  • Existing global safety constraints on total and individual electrode currents may not prevent localized high current densities.

Purpose of the Study:

  • To develop an efficient computational approach to prevent current density hot-spots during ECoG stimulation.
  • To optimize ECoG stimulus patterns for targeted stimulation in a specific region of interest (ROI).
  • To maximize current along a desired directional field within the ROI while adhering to safety constraints.

Main Methods:

  • Proposed an efficient two-step approach to computationally manage numerous local current density constraints.
  • Step 1: Identified safe brain regions based on global current bounds.
  • Step 2: Iteratively adjusted stimulus patterns to eliminate hot-spots in remaining brain areas using a realistic finite element head model.

Main Results:

  • Simulations on a realistic head model demonstrated the efficacy of the proposed method in preventing current density hot-spots.
  • Analyzed the impact of ROI depth and desired directional fields on stimulation focality.
  • Evaluated optimization runtime concerning various safety and modeling parameters.

Conclusions:

  • The developed method efficiently prevents current density hot-spots, enabling safer and more targeted ECoG stimulation.
  • Optimized stimulus patterns derived from this method differ from current clinical practices.
  • This approach holds promise for advancing future applications in cortical modulation and brain-computer interfaces.