Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

12.1K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
12.1K
Amyloid Fibrils03:03

Amyloid Fibrils

6.5K
6.5K
Fibril-associated Collagen01:11

Fibril-associated Collagen

3.4K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.4K
Fixed Action Patterns01:06

Fixed Action Patterns

17.7K
A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
17.7K
Action Potentials01:41

Action Potentials

143.3K
Overview
143.3K
Action Potential01:31

Action Potential

4.8K
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patent Foramen Ovale on Transthoracic Echocardiography and Brain White-Matter Hyperintensities: A Transportability Analysis and Practice-Anchored Risk Framework.

Journal of clinical medicine·2026
Same author

Early Safety Profile Using Pulsed Field Ablation: Prospective Multicenter DISRUPT-AF Study.

JACC. Clinical electrophysiology·2026
Same author

Comparison of tricuspid regurgitation after cardiac resynchronization therapy-defibrillator implantation using left bundle branch area pacing versus biventricular pacing.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
Same author

Linking patent foramen ovale with atrial cardiomyopathy: a narrative review of clinical signals, electrophysiology, and translational opportunities.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
Same author

The present and the future of risk stratification for and prevention of sudden cardiac death: A Heart Rhythm Society think tank meeting.

Heart rhythm·2026
Same author

Multicenter analysis of device-detected atrial fibrillation burden reduction after antiarrhythmic drug initiation.

Heart rhythm O2·2026

Related Experiment Video

Updated: Feb 14, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.6K

When is Device-Detected Atrial Fibrillation Actionable?

Jeremiah Wasserlauf1, Rod S Passman2

  • 1Division of Cardiology, Northwestern University Feinberg School of Medicine, 646 North St. Clair, Suite 600, Chicago, IL 60611, USA.

Cardiac Electrophysiology Clinics
|February 12, 2018
PubMed
Summary

Device-detected atrial high-rate episodes (AHREs) in patients without a history of atrial fibrillation (AF) pose a clinical challenge. Current research explores tailored anticoagulation strategies for these patients, alongside those with known AF.

Keywords:
Atrial fibrillationCardiac implanted electronic devicesDefibrillatorPacemakerStrokeThromboembolism

More Related Videos

Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats
05:12

Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats

Published on: February 14, 2022

3.8K
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

34.2K

Related Experiment Videos

Last Updated: Feb 14, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.6K
Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats
05:12

Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats

Published on: February 14, 2022

3.8K
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

34.2K

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Device-detected atrial high-rate episodes (AHREs) are common in patients without a prior atrial fibrillation (AF) diagnosis.
  • These AHREs present a clinical dilemma as these patients are often excluded from AF therapy trials.
  • Existing AF patients can benefit from continuous monitoring and rapid-acting oral anticoagulants for tailored treatment.

Purpose of the Study:

  • To review current evidence regarding device-detected AHREs.
  • To discuss evolving research into managing patients with AHREs.
  • To highlight the challenges in treating device-detected AF.

Main Methods:

  • Literature review of studies on device-detected AHREs.
  • Analysis of clinical trial data and ongoing investigations.
  • Synthesis of evidence on anticoagulation and rhythm monitoring.

Main Results:

  • AHREs are frequently observed, posing diagnostic and therapeutic challenges.
  • Patients with device-detected AF are underrepresented in clinical trials.
  • Ongoing studies are evaluating the safety of anticoagulation for AHREs.

Conclusions:

  • Device-detected AHREs require further investigation for optimal patient management.
  • Tailored anticoagulation strategies are being explored for patients with AHREs.
  • Continuous monitoring and rapid-acting therapies show promise for AF management.