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Updated: Feb 14, 2026
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
Published on: September 13, 2018
The Role of Hippo Pathway in Cancer Stem Cell Biology
Jae Hyung Park1, Ji Eun Shin1, Hyun Woo Park1
1Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.
Abstract:
The biological significance and deregulation of the Hippo pathway during organ growth and tumorigenesis have received a surge of interest in the past decade. The Hippo pathway core kinases, MST1/2 and LATS1/2, are tumor suppressors that inhibit the oncogenic nuclear function of YAP/TAZ and TEAD. In addition to earlier studies that highlight the role of Hippo pathway in organ size control, cell proliferation, and tumor development, recent evidence demonstrates its critical role in cancer stem cell biology, including EMT, drug resistance, and self-renewal. Here we provide a brief overview of the regulatory mechanisms of the Hippo pathway, its role in cancer stem cell biology, and promising therapeutic interventions.
Insights
The Hippo pathway, involving MST1/2 and LATS1/2 kinases, regulates organ growth and suppresses tumors by inhibiting YAP/TAZ and TEAD. Recent studies highlight its role in cancer stem cells, including EMT and drug resistance.
Area of Science:
- Cell Biology
- Oncology
- Molecular Biology
Background:
- The Hippo pathway is crucial for organ size control and tumor suppression.
- Core kinases MST1/2 and LATS1/2 inhibit oncogenic YAP/TAZ and TEAD.
- Emerging evidence links the Hippo pathway to cancer stem cell (CSC) characteristics.
Purpose of the Study:
- To provide an overview of Hippo pathway regulation.
- To summarize its role in cancer stem cell biology.
- To discuss potential therapeutic strategies.
Main Methods:
- Literature review of recent studies on the Hippo pathway.
- Analysis of the pathway's regulatory mechanisms.
- Synthesis of findings on CSC biology and therapeutic interventions.
Main Results:
- The Hippo pathway's core kinases act as tumor suppressors.
- The pathway is implicated in CSC self-renewal, EMT, and drug resistance.
- Several therapeutic interventions targeting the Hippo pathway are under investigation.
Conclusions:
- The Hippo pathway is a key regulator in both organ development and tumorigenesis.
- Its deregulation significantly impacts cancer stem cell properties.
- Targeting the Hippo pathway presents promising therapeutic avenues for cancer treatment.
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