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IAPs: Mediators of Oncogenesis and Targets for Anticancer Therapy

Sarra Bouaouiche1, Laurence Dubrez2, Ali Bettaieb1

  • 1École Pratique des Hautes Études (EPHE), PSL Research University, Paris, France; Laboratoire d'Immunologie et Immunothérapie des Cancers (LIIC), Université de Bourgogne Franche-Comté, Dijon, France.

Critical Reviews in Oncogenesis
|February 13, 2018
PubMed

Insights

Inhibitor of apoptosis (IAP) proteins regulate cell processes and can promote cancer. Alterations in IAP genes link to oncogenic pathways, particularly nuclear factor-kappa B (NF-κB), suggesting therapeutic potential for IAP antagonists.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Cellular Homeostasis

Background:

  • Inhibitor of apoptosis (IAP) proteins are crucial regulators of fundamental cellular processes, including cell death, proliferation, differentiation, and inflammation.
  • Emerging evidence indicates that certain IAP family members exhibit oncogenic properties, contributing to cancer development.
  • Genomic database analysis reveals genetic alterations in IAP genes, leading to functional gains or losses in tumors.

Purpose of the Study:

  • To review the role of IAP alterations in cell transformation and their connection to oncogenic pathways.
  • To focus on the link between IAP alterations and nuclear factor-kappa B (NF-κB)-activating signaling pathways.
  • To highlight the therapeutic potential of IAP antagonists and nitric oxide (NO) donors in anticancer strategies targeting NF-κB.

Main Methods:

  • Review of genomic database analyses from tumor sequencing studies.
  • Analysis of scientific literature on IAP family members and their oncogenic roles.
  • Discussion of signaling pathways, specifically NF-κB activation by IAPs.

Main Results:

  • IAP alterations are implicated in cell transformation and cancer progression.
  • A significant link exists between IAP alterations and NF-κB signaling pathways.
  • IAP antagonists and NO donors show promise as therapeutic agents by inhibiting NF-κB.

Conclusions:

  • IAP gene alterations play a critical role in oncogenesis.
  • Targeting IAP-mediated NF-κB activation presents a viable anticancer therapeutic strategy.
  • IAP antagonists and NO donors represent promising therapeutic avenues for cancer treatment.

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