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Analytical Techniques for Assaying Nitric Oxide Bioactivity
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Published on: June 18, 2012

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Therapeutic Potential of Nitric Oxide Donors in Cancer: Focus on Angiogenesis

Lucia Morbidelli1

  • 1Lab of Pharmacology of Angiogenesis and Microcirculation, Department of Life Sciences, University of Siena Via A. Moro 2, 53100 Siena, Italy.

Critical Reviews in Oncogenesis
|February 13, 2018
PubMed

Insights

Novel nitric oxide (NO) donors offer a new strategy against tumor resistance. High doses of NO show significant antitumor and antiangiogenic effects, crucial for cancer therapy development.

Area of Science:

  • Oncology
  • Pharmacology
  • Biomedical Engineering

Background:

  • Tumor resistance to conventional treatments remains a significant clinical challenge.
  • Nitric oxide (NO) exhibits dual roles in cancer, with low doses promoting tumor growth and high doses inhibiting it.
  • Exogenous NO administration is being explored as a therapeutic strategy.

Purpose of the Study:

  • To review the role of exogenous nitric oxide (NO) in cancer therapy.
  • To summarize the current state of NO-donating agents for cancer treatment.
  • To highlight the antiangiogenic potential of NO in preclinical and clinical settings.

Main Methods:

  • Literature review of studies on nitric oxide donors in cancer therapy.
  • Analysis of preclinical and clinical data on NO-based cancer treatments.
  • Focus on mechanisms of NO-induced antiangiogenesis.

Main Results:

  • High-dose exogenous NO demonstrates potent antitumor and antiangiogenic activities.
  • Various NO-donating agents are under investigation for their therapeutic efficacy.
  • NO influences multiple pathways involved in tumor growth and vascularization.

Conclusions:

  • Novel nitric oxide donors represent a promising approach to overcome tumor resistance.
  • Targeted delivery and high-dose administration of NO are key for therapeutic success.
  • Further research into NO-based therapies, particularly for angiogenesis inhibition, is warranted.

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