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Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
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Imaging of mast cells.

Shweta Tikoo1,2, Natasja Barki3, Rohit Jain1,2

  • 1The Centenary Institute, Newtown, NSW, Australia.

Immunological Reviews
|February 13, 2018
PubMed
Summary

Mast cells, key immune cells, are visualized using advanced imaging techniques. This allows real-time observation of their behavior in tissues, enhancing our understanding of immune responses in health and disease.

Keywords:
cell lineages and subsetsenteric nervous systemex vivo imaging techniquesin vivo imaging techniquesmast cells/basophilsneuro-immune-signaling

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Area of Science:

  • Immunology
  • Cell Biology
  • Microscopy

Background:

  • Mast cells are crucial innate immune cells involved in allergies and host-pathogen interactions.
  • Traditional studies relied on in vitro and tissue section analyses using light and electron microscopy.
  • Recent advancements enable in situ visualization of mast cell behavior.

Purpose of the Study:

  • To review common imaging approaches for studying mast cells.
  • To illustrate mast cell function through imaging, focusing on gut mast cell-nerve interactions.
  • To highlight how imaging advances our understanding of mast cells in health and disease.

Main Methods:

  • Review of established and novel imaging techniques.
  • In vitro cell culture imaging.
  • Intravital microscopy and fluorescent reporter strains.
  • Analysis of mast cell-nerve plexus interactions in the intestinal tract.

Main Results:

  • Imaging provides real-time, in situ data on mast cell behavior.
  • Detailed visualization of mast cell distribution, morphology, and function.
  • Established a link between mast cell imaging and understanding their role in disease.

Conclusions:

  • Visualizing mast cells offers unprecedented insights into their dynamic roles.
  • Advanced imaging techniques are essential for studying mast cells in complex biological systems.
  • This approach broadens the perspective on mast cells in both physiological and pathological conditions.