Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

6.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.6K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.2K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

4.1K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ponatinib in CML and Ph+ ALL: balancing high efficacy with vascular safety.

Postgraduate medicine·2026
Same author

S-phase targeted treatment triggers caspase-dependent lytic immunogenic cell death with pyroptotic features in cancers.

Cell death and differentiation·2026
Same author

Beyond ST Elevation: Recognizing Wellens Syndrome and the de Winter Pattern as High-Risk LAD Ischemia.

Cardiology in review·2026
Same author

Multivariate assessment of morphological diversity in Moringa oleifera Lam. across agro-climatic zones of Rajasthan.

BMC ecology and evolution·2026
Same author

Venopulmonary Extracorporeal Membrane Oxygenation: Overview, Applications, and Current Evidence.

Cardiology in review·2026
Same author

Regulatory dynamics of molecular determinants in divergent rice varieties under the influence of nano-structured Zinc: an integrative study of OsbZIP genes and their targeting miRNAs.

BMC plant biology·2026

Related Experiment Video

Updated: Mar 29, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

16.8K

The Emerging Melanoma Management: Historical Perspective to Future Directions.

Shin Yee Hui1,2, Rohit Jain3, Nikolas K Haass4

  • 1Department of Anatomical and Cellular Pathology and State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

Cancers
|March 28, 2026
PubMed
Summary

Advanced melanoma treatment has evolved significantly, with immune checkpoint inhibitors and targeted therapies improving outcomes. Future research focuses on enhancing these treatments and exploring novel strategies like CAR-T/NK cell therapies.

Keywords:
immunotherapymelanomaskin cancertargeted therapy

More Related Videos

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

9.7K
A Melanoma Patient-Derived Xenograft Model
07:07

A Melanoma Patient-Derived Xenograft Model

Published on: May 20, 2019

13.3K

Related Experiment Videos

Last Updated: Mar 29, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

16.8K
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

9.7K
A Melanoma Patient-Derived Xenograft Model
07:07

A Melanoma Patient-Derived Xenograft Model

Published on: May 20, 2019

13.3K

Area of Science:

  • Oncology
  • Dermatology
  • Cancer Research

Background:

  • Cutaneous melanoma is a deadly skin cancer, causing most skin cancer mortality.
  • Treatment has advanced rapidly in the last 20 years.
  • Immune checkpoint inhibitors and targeted therapies have improved advanced melanoma outcomes.

Purpose of the Study:

  • To review the evolution of advanced melanoma therapies over 50 years.
  • To discuss current and emerging melanoma biomarkers and treatment recommendations.
  • To explore ongoing clinical trials and future therapeutic strategies.

Main Methods:

  • Literature review of melanoma treatment evolution.
  • Analysis of therapeutic strategies, biomarkers, and clinical trial data.
  • Synthesis of historical and current treatment approaches.

Main Results:

  • Significant progress in advanced melanoma management through immunotherapy and targeted drugs.
  • Identification of key biomarkers influencing treatment selection.
  • Ongoing trials explore combination therapies and novel agents.

Conclusions:

  • Improving immune checkpoint blockade efficacy is crucial for advanced melanoma.
  • Emerging therapies like CAR-T/NK, PROTAC, and extracellular vesicles show promise.
  • Continued research is vital for better melanoma patient outcomes.