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The possible relationship between Campylobacter spp./Arcobacter spp. and patients with ulcerative colitis
Mustafa Akar1, Fuat Aydin2, Mustafa A Yurci1
1Departments of Gastroenterology.
European Journal of Gastroenterology & Hepatology
|February 13, 2018
Summary
Campylobacter spp. may trigger ulcerative colitis (UC) flare-ups but do not initiate the disease. Arcobacter spp. were not found in UC patients, suggesting no link to this inflammatory bowel disease.
Area of Science:
- Gastroenterology
- Microbiology
- Inflammatory Bowel Disease Research
Background:
- Investigating the role of bacterial infections in ulcerative colitis (UC) pathogenesis.
- Examining the prevalence and impact of Campylobacter and Arcobacter species in UC patients.
Purpose of the Study:
- Determine the prevalence of Campylobacter and Arcobacter spp. in UC patients.
- Assess antibiotic susceptibility of isolated bacteria.
- Investigate the role of these microbes in UC pathogenesis and activation.
Main Methods:
- Cultured stool samples from 80 UC patients and 40 healthy controls.
- Utilized direct plating, membrane filtration, and enrichment for bacterial isolation.
- Employed 16S rRNA sequencing for definitive identification of isolates.
Main Results:
- Campylobacter spp. found in 5% of UC patients (C. curvus, C. concisus, C. sputorum, C. jejuni).
- Antibiotic resistance observed in C. concisus and C. jejuni against ciprofloxacin, levofloxacin, trimethoprim-sulfamethoxazole, and tetracycline.
- No Arcobacter spp. detected in UC or control groups.
Conclusions:
- Campylobacter spp. likely exacerbate existing UC, acting as a superimposed infection rather than a primary cause.
- Arcobacter spp. show no association with UC, despite their known role in gastroenteritis.
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