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Different macaque models of cognitive aging exhibit task-dependent behavioral disparities.
Alison E Comrie1, Daniel T Gray1, Anne C Smith2
1Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, 85724, USA; Division of Neural Systems, Memory & Aging, University of Arizona, Tucson, AZ, 85724, USA.
Behavioural Brain Research
|February 13, 2018
Summary
Cognitive aging differs between rhesus and bonnet macaques. Bonnet macaques show better prefrontal cortex function and resilience to aging, unlike rhesus macaques, impacting brain senescence models.
Area of Science:
- Neuroscience
- Comparative Psychology
- Aging Research
Background:
- Human aging involves cognitive decline linked to frontal and temporal lobes.
- Nonhuman primates are used as models for brain senescence due to similar aging.
- Rhesus and bonnet macaques are common models, but their equivalence is unproven.
Purpose of the Study:
- To compare cognitive aging in rhesus and bonnet macaques.
- To investigate age-related changes in prefrontal cortex and medial temporal lobe functions.
- To determine if these macaque species are equivalent models of cognitive aging.
Main Methods:
- Adult and aged rhesus and bonnet macaques were tested.
- A battery of behavioral tasks assessed visuospatial memory, object recognition, and object-reward association.
- Tasks targeted prefrontal cortex and medial temporal lobe networks.
Main Results:
- Bonnet macaques outperformed rhesus macaques on prefrontal cortex-dependent tasks.
- Bonnet macaques exhibited greater resilience to age-related cognitive deficits.
- Both species showed comparable age-related impairments in medial temporal lobe-dependent tasks.
Conclusions:
- Rhesus and bonnet macaques are not equivalent models for cognitive aging research.
- Species-specific differences in cognitive aging should be considered.
- Cross-species comparisons are valuable for understanding brain senescence.
Keywords:
Bonnet macaquesObject recognition memoryObject-reward association memoryRhesus macaquesVisuospatial short-term memoryWGTAMore Related Videos
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