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Finite Element Modelling of a Cellular Electric Microenvironment
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Maximizing the information learned from finite data selects a simple model.

Henry H Mattingly1,2, Mark K Transtrum3, Michael C Abbott4

  • 1Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544.

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|February 14, 2018
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Summary
This summary is machine-generated.

This study proposes a Bayesian prior that maximizes information from limited data, simplifying models by focusing on essential parameters. This principled approach avoids overfitting and selects effective theories by ignoring unconstrained parameter directions.

Keywords:
Bayesian prior choiceeffective theoryinformation theorymodel selectionrenormalization group

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Area of Science:

  • Statistical modeling
  • Model selection
  • Bayesian inference

Background:

  • Selecting simple yet effective models is crucial in scientific research.
  • Traditional methods may struggle with high-dimensional parameter spaces and limited data.
  • Uninformative Bayesian priors are key to robust model selection.

Purpose of the Study:

  • To develop a principled method for selecting simple effective models using Bayesian inference.
  • To advocate for a specific prior that optimizes learning from limited data.
  • To address the challenges of parameter space complexity in scientific modeling.

Main Methods:

  • Utilizing the framework of uninformative Bayesian prior choice.
  • Advocating for a prior that maximizes mutual information between parameters and predictions.
  • Analyzing the behavior of this prior when parameters are poorly constrained.

Main Results:

  • The proposed prior concentrates weight on parameter space boundaries when data is limited.
  • This effectively selects lower-dimensional theories by ignoring irrelevant parameter directions.
  • In data-rich limits, the prior converges to the Jeffreys prior.

Conclusions:

  • The advocated prior offers a principled way to achieve model simplicity and effective learning.
  • It provides a robust alternative to the Jeffreys prior in scenarios with limited or high-dimensional data.
  • This approach helps avoid pathological dependencies on unobservable effects in scientific models.