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Updated: Feb 14, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
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Published on: September 18, 2013

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Function of Axl receptor tyrosine kinase in non-small cell lung cancer

Guoan Zhang1, Meng Wang2, Hongli Zhao3

  • 1Cancer Pathology Research Institute, Jining Medical University, Jining, Shandong 272067, P.R. China.

Oncology Letters
|February 14, 2018
PubMed

Insights

Axl receptor tyrosine kinase (Axl) is overexpressed in non-small cell lung cancer (NSCLC), promoting tumor growth and resistance. Targeting Axl may offer a promising therapeutic strategy for NSCLC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Axl receptor tyrosine kinase (Axl) plays diverse roles in normal cellular functions.
  • Axl is frequently overexpressed and activated in various human cancers, driving tumor progression.
  • This review focuses on the specific role of Axl in non-small cell lung cancer (NSCLC).

Purpose of the Study:

  • To review and assess existing studies on the function of Axl in NSCLC.
  • To evaluate the clinical significance of Axl overexpression in NSCLC.
  • To explore Axl as a potential therapeutic target for NSCLC.

Main Methods:

  • Literature review of previous studies on Axl in NSCLC.
  • Analysis of data linking Axl expression to clinical outcomes.
  • Assessment of Axl's impact on key cancer hallmarks.

Main Results:

  • Axl is overexpressed in NSCLC tumor tissues and correlates with poor clinical outcomes.
  • Axl promotes NSCLC tumor growth, invasion, and metastasis.
  • Axl contributes to drug resistance and epithelial-mesenchymal transition in NSCLC, enhancing tumor cell survival.

Conclusions:

  • Axl plays a significant role in promoting NSCLC progression and survival.
  • Axl represents a promising molecular target for novel NSCLC therapeutic strategies.
Keywords:
Axl receptor tyrosine kinasedrug resistanceepithelial-mesenchymal transitioninvasionmetastasisnon-small cell lung cancer

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