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Updated: Feb 14, 2026
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Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients
Published on: September 25, 2018
11.1K
Prognostic value of PD -L1 expression in patients with primary solid tumors
Xiao Xiang1, Peng-Cheng Yu2, Di Long2
1Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China.
Oncotarget
|February 14, 2018
Summary
Programmed death-ligand 1 (PD-L1) expression in solid tumors is linked to poorer overall survival (OS). This meta-analysis confirms PD-L1 as a negative prognostic indicator and potential therapeutic target in cancer patients.
Area of Science:
- Oncology
- Immunology
- Biostatistics
Background:
- Programmed death-ligand 1 (PD-L1) is implicated in cancer immune evasion.
- The prognostic significance of PD-L1 expression in solid tumors remains debated.
Purpose of the Study:
- To meta-analyze existing data on the correlation between PD-L1 expression and overall survival (OS) in patients with solid tumors.
- To determine if PD-L1 expression is a reliable prognostic indicator.
Main Methods:
- Systematic literature search of PubMed, EMBASE, and other databases for cohort and case-control studies.
- Meta-analysis of data from 59 studies including 20,004 patients with solid tumors.
- Subgroup analyses were conducted based on tumor type and patient characteristics.
Main Results:
- PD-L1-positive patients exhibited significantly lower OS at 1, 3, and 5 years compared to PD-L1-negative patients.
- Risk ratios for OS were 2.02 (1-year), 1.57 (3-year), and 1.43 (5-year).
- Consistent negative prognostic impact of PD-L1 was observed across various tumor types and ethnicities.
Conclusions:
- PD-L1 expression is associated with a poorer prognosis in patients with solid tumors.
- PD-L1 may serve as an effective prognostic biomarker for solid tumors.
- PD-L1 represents a potential therapeutic target for improving cancer patient outcomes.
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