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Updated: Feb 14, 2026

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
Published on: April 22, 2015
Electrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in
Jennifer H Foss-Feig1,2, Katherine K M Stavropoulos3, James C McPartland4,5
1a Department of Psychiatry , Icahn School of Medicine at Mount Sinai Hospital , One Gustave Levy Place, New York , New York.
Abstract:
Sensory symptoms, including auditory processing deficits, are common in autism spectrum disorder (ASD). Processing of temporal aspects of auditory input is understudied; yet, deficits in this domain could contribute to language-related impairments. In children with ASD and well-matched controls, this study examined electrophysiological response to silent gaps in auditory stimuli. Results revealed attenuated amplitude of the P2 event-related potential (ERP) component in ASD. The P2 amplitude reduction was also associated with sensory, language, and diagnostic features. These results suggest that neural response during auditory gap detection is a promising ASD biomarker that could be useful for stratifying subgroups and evaluating treatment response.
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