Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multisteroid analysis after DST in depressed patients--a controlled study.

F Holsboer, M Philipp, A Steiger

    Journal of Affective Disorders
    |May 1, 1986
    PubMed
    Summary

    The dexamethasone suppression test (DST) shows moderate predictive value for diagnosing depression subtypes. Analyzing multiple steroids, including dexamethasone, is crucial for improving diagnostic accuracy in clinical studies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correction: Non-Response to Antidepressants: Risk Factors and Therapeutic Possibilities.

    Pharmacopsychiatry·2026
    Same author

    Development of Superconducting On-chip Fourier Transform Spectrometers.

    Journal of low temperature physics·2022
    Same author

    Durable memories and efficient neural coding through mnemonic training using the method of loci.

    Science advances·2021
    Same author

    The renin secretion profile under the influence of sleep deprivation and the neuropeptides CRH and GHRH.

    Psychoneuroendocrinology·2020
    Same author

    Salivary cortisol response to psychosocial stress in the late evening depends on CRHR1 genotype.

    Psychoneuroendocrinology·2020
    Same author

    Indocyanine Green Fluorescence Angiography Can Guide Intraoperative Localization During Parathyroid Surgery.

    Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society·2019

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Endocrinology

    Background:

    • The dexamethasone suppression test (DST) is a biomarker used in diagnosing depressive disorders.
    • Accurate diagnostic criteria are essential for effective depression treatment.

    Purpose of the Study:

    • To evaluate the diagnostic performance of the DST in patients with depressive syndrome.
    • To assess the utility of analyzing multiple steroids (cortisol, corticosterone, dexamethasone) in conjunction with diagnostic evaluations.

    Main Methods:

    • 111 inpatients with depressive syndrome underwent DST after excluding confounding factors.
    • Plasma levels of cortisol, corticosterone, and dexamethasone were measured.
    • Results were compared with diagnostic evaluations (RDC, DSM-III, ICD-9).

    Related Experiment Videos

    Main Results:

    • The positive predictive value of nonsuppressed corticosteroid levels was moderate across diagnostic categories.
    • Diagnostic specificities ranged from 71.2% to 86.8% for different depression subtypes.
    • Combined steroid analysis improved sensitivity but reduced predictive value; considering dexamethasone levels enhanced performance for some diagnoses.

    Conclusions:

    • The DST demonstrates moderate diagnostic utility for depression subtypes.
    • Multisteroid analysis, including dexamethasone, is important for future DST research and clinical application.
    • Further investigation is needed to understand the role of dexamethasone levels in DST nonsuppression.