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Down's syndrome and the gastrointestinal tract.

P J Buchin, J S Levy, J N Schullinger

    Journal of Clinical Gastroenterology
    |April 1, 1986
    PubMed
    Summary

    Gastrointestinal issues are common in Down syndrome. Duodenal stenosis, a severe GI disorder, had a high mortality rate of 56% in patients with Down syndrome.

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    Area of Science:

    • Pediatrics
    • Gastroenterology
    • Genetics

    Background:

    • Gastrointestinal (GI) abnormalities are frequently observed in individuals with Down syndrome.
    • Understanding the spectrum and outcomes of these GI conditions is crucial for patient care.

    Purpose of the Study:

    • To review the incidence and types of major GI disorders in patients with Down syndrome.
    • To determine the mortality rates associated with these GI disorders, particularly duodenal stenosis.

    Main Methods:

    • A 12-year retrospective review of 187 patients with Down syndrome admitted to a major medical center.
    • Identification and categorization of major GI disorders, including duodenal stenosis (DS), gastroesophageal reflux (GER), imperforate anus, and Hirschsprung's disease.

    Main Results:

    • Twenty-seven patients (14.4%) had major GI disorders.
    • Duodenal stenosis was the most common major GI disorder (nine patients), with a high mortality rate of 56% (five deaths).
    • Overall mortality for the group was 11% (20 patients), with pneumonia and congenital heart disease (especially endocardial cushion defects) as contributing factors.

    Conclusions:

    • Gastrointestinal abnormalities are a significant concern in Down syndrome.
    • Duodenal stenosis presents a particularly high mortality risk in this population.
    • Multifactorial causes, including cardiac defects and pneumonia, contribute to the overall mortality in Down syndrome patients with GI issues.

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