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An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
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Stem cell mobilization kinetics in elderly patients with multiple myeloma

Mehmet Hilmi Dogu1, Hikmetullah Batgi2, Mehmet Ali Erkurt3

  • 1Istanbul Education and Research Hospital, Hematology Clinic, Istanbul, Turkey.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|February 15, 2018
PubMed

Insights

Advanced-age multiple myeloma patients undergoing autologous stem cell transplant showed shorter procedure times in older age groups. Successful stem cell mobilization is achievable in selected elderly patients.

Area of Science:

  • Hematology
  • Oncology
  • Transplantation Medicine

Background:

  • Autologous hematopoietic stem cell transplantation (HSCT) is a cornerstone therapy for multiple myeloma (MM).
  • Assessing the impact of advanced age on HSCT procedure and product kinetics is crucial for optimizing patient selection and outcomes.

Purpose of the Study:

  • To investigate age-related differences in procedure and product kinetics during autologous HSCT in advanced-age MM patients.
  • To determine if stem cell mobilization and collection parameters vary between younger elderly (60-65 years) and older elderly (≥65 years) MM patients.

Main Methods:

  • Retrospective analysis of 59 advanced-age MM patients who underwent autologous HSCT.
  • Patients were stratified into two age groups: 60-65 years and ≥65 years.
  • Comparison of procedure duration and CD34+ stem cell collection yields between the two age groups.

Main Results:

  • The procedure duration was significantly shorter in the ≥65 years group (p=0.013).
  • The number of collected CD34+ stem cells did not significantly differ between the 60-65 years (6.20×10^6 ±3.83) and ≥65 years (5.51×10^6 ±2.48) groups (p=0.825).

Conclusions:

  • Advanced age does not significantly impact the number of collected CD34+ stem cells in MM patients undergoing autologous HSCT.
  • Successful stem cell mobilization is feasible in appropriately selected elderly patients, irrespective of age.
  • Age should not be an absolute contraindication for autologous HSCT in MM if patients are carefully selected.

Keywords:
ApheresisMobilizationMultiple myeloma

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