Related Experiment Video

Updated: Feb 14, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
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Targeting HSF1: A Prime Integrator of Proteotoxic Stress Response in Myeloma

Samir Parekh1

  • 1Department of Hematology Oncology, Icahn School of Medicine at Mount Sinai, New York, New York. samir.parekh@mssm.edu.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|February 15, 2018
PubMed

Insights

New small-molecule inhibitors targeting heat shock factor 1 (HSF1) show promise against multiple myeloma. These compounds demonstrate antimyeloma activity in vitro and in vivo, offering a novel therapeutic strategy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cellular Stress Response

Background:

  • Heat shock factor 1 (HSF1) is crucial for cellular stress response.
  • Elevated HSF1 expression correlates with poor prognosis in multiple myeloma.

Purpose of the Study:

  • To investigate the antimyeloma activity of novel small-molecule inhibitors targeting HSF1.
  • To evaluate the therapeutic potential of targeting the heat shock response pathway in multiple myeloma.

Main Methods:

  • Utilized novel small-molecule inhibitors, CCT251236 and KRIB11, designed to inhibit HSF1.
  • Assessed the efficacy of these inhibitors through in vitro and in vivo studies in multiple myeloma models.

Main Results:

  • The HSF1 inhibitors CCT251236 and KRIB11 exhibited significant antimyeloma activity.
  • Demonstrated effectiveness in both laboratory (in vitro) and living organism (in vivo) settings.

Conclusions:

  • Novel anti-HSF1 small-molecule inhibitors represent a promising new therapeutic approach for multiple myeloma.
  • Targeting the heat shock response pathway via HSF1 inhibition offers a viable strategy for treating this hematologic malignancy.

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