Multivariate resting-state functional connectivity predicts response to cognitive behavioral therapy in
Nicco Reggente1, Teena D Moody2, Francesca Morfini2
1Department of Psychology, University of California, Los Angeles, CA 90095; nreggente@psych.ucla.edu.
Summary
Predicting treatment success for obsessive-compulsive disorder (OCD) is possible. Resting-state brain connectivity patterns before treatment can forecast how well individuals will respond to cognitive behavioral therapy (CBT).
Area of Science:
- Neuroscience
- Psychiatry
- Machine Learning
Background:
- Cognitive behavioral therapy (CBT) is a primary treatment for obsessive-compulsive disorder (OCD).
- Individual responses to CBT for OCD vary significantly, necessitating predictive tools for personalized treatment allocation.
- Predictive biomarkers are needed to optimize resource allocation for intensive, time-consuming OCD therapies.
Purpose of the Study:
- To investigate the predictive power of resting-state functional connectivity (FC) patterns for individual treatment response in OCD patients undergoing CBT.
- To determine if neuroimaging-based FC metrics can predict post-treatment symptom severity more effectively than clinical assessments.
Main Methods:
- Resting-state functional magnetic resonance imaging (fMRI) data were acquired from adults with OCD before and after 4 weeks of intensive daily CBT.
- Machine learning algorithms with cross-validation were employed to analyze pretreatment FC patterns.
- The predictive accuracy of FC patterns within specific brain networks (default mode network, visual network) for post-treatment OCD symptom severity was assessed.
Main Results:
- Pretreatment functional connectivity (FC) patterns within the default mode network and visual network significantly predicted post-treatment OCD symptom severity.
- These FC patterns explained up to 67% of the variance in treatment response.
- Neuroimaging-based FC predictors demonstrated superior predictive power compared to pretreatment clinical scores.
Conclusions:
- Resting-state FC patterns hold significant potential as biomarkers for predicting individual treatment outcomes in OCD.
- These findings support the development of personalized medicine approaches to identify OCD patients most likely to benefit from intensive CBT.
- Integrating neuroimaging data into clinical practice could enhance the efficacy and efficiency of OCD treatment.
Related Concept Videos
01:28Obsessive-Compulsive Disorder
651
Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
651
01:24Personality Disorders: Dependent and Obsessive-Compulsive
468
Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle...
Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle...
468
01:25Cognitive Therapy
1.3K
Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
1.3K
01:23Cognition and Behavior
386
Social psychology examines the complex interplay between individual mental processes and social interactions. Historically, the field was divided into two domains: social behavior and social cognition. Researchers focusing on social behavior analyzed actions within social contexts, such as conformity, aggression, or cooperation. Meanwhile, social cognition researchers investigated how people perceive, interpret, and mentally represent their social environments. However, modern perspectives no...
386
01:25Beck's Cognitive Therapy
409
Cognitive therapy is a psychological approach designed to address distortions in thinking, which can lead to negative emotions and unrealistic beliefs. These cognitive distortions often influence how individuals interpret and respond to situations, exacerbating emotional distress. Below are some prevalent cognitive distortions, their characteristics, and examples of how they manifest in thought processes.
Arbitrary Inference
Arbitrary inference involves making conclusions without sufficient...
Arbitrary Inference
Arbitrary inference involves making conclusions without sufficient...
409
01:22Behavior Therapy
752
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
752