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γδ T cells in liver diseases

Xuefu Wang1, Zhigang Tian2,3

  • 1School of Pharmacy, Anhui Medical University, Hefei, 230032, China. wangxuefu@ustc.edu.cn.

Frontiers of Medicine
|February 15, 2018
PubMed

γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit liver-specific features. Accumulating evidence reveals that γδ T cells play important roles in liver infection, non-alcoholic fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regeneration. In this study, we review the properties of hepatic γδ T cells and summarize the roles of γδ T cells in liver diseases. We believe that determining the properties and functions of γδ T cells in liver diseases enhances our understanding of the pathogenesis of liver diseases and is useful for the design of novel γδ T cell-based therapeutic regimens for liver diseases.

Keywords:
autoimmune hepatitisliver cancerliver fibrosis and cirrhosisliver infectionliver regenerationnon-alcoholic fatty liver diseaseγδT cells

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