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Related Experiment Video

Updated: Feb 14, 2026

Isolating Myofibrils from Skeletal Muscle Biopsies and Determining Contractile Function with a Nano-Newton Resolution Force Transducer

Isolating Myofibrils from Skeletal Muscle Biopsies and Determining Contractile Function with a Nano-Newton Resolution Force Transducer

Published on: May 7, 2020

[Relationship between Myofibril Fragmentation Index and Postmortem Interval].

L Shen¹, R Z Rui², J Bian³

¹Institute of Forensic Science, Yinchuan Public Security Bureau, Yinchuan 750001, China.

Fa Yi Xue Za Zhi

|February 15, 2018

Summary

This summary is machine-generated.

The myofibril fragmentation index (MFI) of skeletal muscle increases with postmortem interval (PMI), peaking around 12 hours. This MFI measurement is a reliable indicator for estimating early postmortem intervals in forensic investigations.

Keywords:

forensic pathology muscle, skeletal myofibril fragmentation index postmortem interval

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Area of Science:

Forensic Science
Biochemistry
Human Anatomy

Background:

Accurate estimation of postmortem interval (PMI) is crucial in forensic investigations.
Skeletal muscle undergoes degradation postmortem, influencing biochemical markers.
The myofibril fragmentation index (MFI) is a potential indicator of tissue changes over time.

Purpose of the Study:

To investigate the correlation between the myofibril fragmentation index (MFI) of human skeletal muscle and the postmortem interval (PMI).
To establish a quantitative relationship for estimating early PMI using MFI.
To assess the utility of MFI in forensic practice.

Main Methods:

Protein concentration of skeletal muscle (biceps brachii and quadriceps femoris) was measured using the biuret method.
Myofibril fragmentation index (MFI) was determined spectrophotometrically at 540 nm.
Regression analysis was employed to correlate MFI with time since death.

Main Results:

MFI of skeletal muscle showed a significant increase with prolonged PMI, particularly within the first 12 hours postmortem.
Regression equations were derived for biceps brachii (y=32.660+3.227x, r=0.9879) and quadriceps femoris (y=32.380+3.495x, r=0.9839) within 12 hours.
MFI tended to stabilize after peaking around 12 hours postmortem.

Conclusions:

A strong correlation exists between MFI and PMI.
MFI is a valuable tool for estimating early postmortem intervals, especially within the first 12 hours.
The findings support the integration of MFI analysis into routine forensic practice for PMI determination.