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Urinary bisphenol A concentrations in relation to asthma in a sample of Egyptian children

M M Youssef1, Ems El-Din1, M M AbuShady1

  • 11 Department of Child Health, National Research Centre (NRC), Cairo, Egypt.

Human & Experimental Toxicology
|February 15, 2018
PubMed

Insights

Higher urinary bisphenol A (BPA) levels are linked to childhood asthma. This plastic chemical may be a significant risk factor for pediatric asthma development, even more so than passive smoking.

Area of Science:

  • Environmental Health
  • Pediatric Pulmonology
  • Toxicology

Background:

  • Childhood asthma is a major pediatric health concern.
  • Limited research exists on the link between bisphenol A (BPA) and childhood asthma.
  • BPA is a widely used plastic monomer with potential health implications.

Purpose of the Study:

  • To compare urinary BPA levels in children with and without asthma.
  • To investigate BPA's role as a risk factor for childhood asthma development.
  • To assess BPA's significance relative to other asthma risk factors.

Main Methods:

  • A case-control study involving 97 children (ages 3-8).
  • Asthma diagnosis based on Global Initiative for Asthma (GINA) guidelines.
  • Urinary BPA levels measured using high-performance liquid chromatography in spot urine samples.

Main Results:

  • Asthmatic children had significantly higher median urinary BPA levels than controls (1.56 vs. 0.790 ng/mL).
  • Children with urinary BPA levels >1.3 ng/mL were 2.84 times more likely to have asthma.
  • Higher BPA levels were a more significant predictor of asthma than passive smoking.

Conclusions:

  • Elevated urinary BPA levels are associated with childhood asthma diagnosis.
  • BPA exposure may be a risk factor in the development of pediatric bronchial asthma.
  • Further research is needed to elucidate the precise mechanisms linking BPA and asthma.
Abstract

Keywords:
Asthmabisphenol Achildrensmoking

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