The association between the increase in pulse pressure and renal function in chronic kidney disease patients with...

Area of Science:

• Nephrology
• Cardiology
• Internal Medicine

Background:

• Chronic kidney disease (CKD) is increasingly associated with arteriosclerosis.
• Pulse pressure (PP) serves as an indicator of arteriosclerosis.
• Limited research exists on the link between PP and renal dysfunction in CKD patients.

Purpose of the Study:

• To investigate the association between elevated PP and renal function in CKD patients with dyslipidemia.
• To determine if PP predicts changes in renal function over time.

Main Methods:

• A study of 104 CKD patients with dyslipidemia on drug treatment.
• Patients were categorized into High PP (≥65 mmHg) and Low PP (<65 mmHg) groups.
• Analysis included logistic regression and comparison of renal function markers (BUN, Ccr, eGFR) at baseline and 12 months.

Main Results:

• Estimated glomerular filtration rate (eGFR) was a significant predictor of High PP (≥65 mmHg).
• In the High PP group, BUN levels increased significantly, while Ccr and eGFR significantly decreased after 12 months.
• The Low PP group did not show these significant changes.

Conclusions:

• Elevated pulse pressure is associated with accelerated renal function decline in CKD patients with dyslipidemia.
• PP may serve as a valuable auxiliary marker for generalized arterial sclerosis and renal function.
• Further research is warranted to explore therapeutic interventions targeting PP in CKD.