smartLipids^® as third solid lipid nanoparticle generation - stabilization of retinol for dermal application

Area of Science:

• Pharmaceutical Technology
• Materials Science
• Cosmetic Science

Background:

• smartLipids® represent a third-generation lipid nanoparticle (LNP) system.
• Their complex lipid matrix offers superior loading and protection for active ingredients.
• This technology enables advanced formulations for chemically sensitive molecules.

Purpose of the Study:

• To develop an optimized retinol formulation using smartLipids®.
• To investigate the core-shell stabilization model within smartLipids®.
• To evaluate the physical and chemical stability of retinol-loaded LNPs.

Main Methods:

• smartLipids® were produced via hot high-pressure homogenization.
• Particles were loaded with varying retinol concentrations (5%, 15%, 20%).
• Physical (size, crystallinity) and chemical stability were assessed over time.

Main Results:

• Retinol stability increased with higher loading concentrations (75% retention at 20% loading after 60 days).
• Particle size remained stable at approximately 200 nm.
• Absence of polymorphic transitions prevented active expulsion and degradation.

Conclusions:

• The core-shell model effectively protects retinol within smartLipids®.
• Increased retinol loading enhances chemical stability.
• This LNP approach is transferable to other labile cosmetic and pharmaceutical actives.