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PLGA Implants containing vancomycin and dexamethasone: development, characterization and bactericidal effects
Die Pharmazie
|February 15, 2018
Summary
New poly(lactic-co-glycolic acid) (PLGA) implants deliver vancomycin and dexamethasone to treat post-operative endophthalmitis, offering a potential alternative to eye injections.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Infectious Diseases
Background:
- Post-operative endophthalmitis is a severe ocular infection following eye surgery.
- Current treatment involves intraocular drug injections, which can cause complications.
- Intraocular implants offer a potential alternative drug delivery system.
Purpose of the Study:
- To evaluate poly(lactic-co-glycolic acid) (PLGA) implants loaded with vancomycin and dexamethasone.
- To assess their efficacy as a drug delivery system for treating endophthalmitis after cataract surgery.
Main Methods:
- Characterization of PLGA implants using FTIR, DSC, WAXS, and SEM.
- Assessment of drug content uniformity and in vitro drug release kinetics.
- Evaluation of the bactericidal effect of eluted vancomycin against Staphylococcus aureus and epidermidis.
Main Results:
- Drugs were uniformly distributed within the PLGA polymer matrix.
- Analytical techniques confirmed the chemical integrity of incorporated drugs.
- Controlled drug release was observed, with eluted vancomycin demonstrating bactericidal activity.
- Dexamethasone's semi-crystalline nature was modified within the implant.
Conclusions:
- PLGA implants effectively deliver vancomycin and dexamethasone for controlled release.
- These implants show promise as a therapeutic alternative for post-operative endophthalmitis.
- This approach may reduce complications associated with conventional intraocular injections.
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