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Exercise induced asthma and endogenous opioids.

R C Gaillard, M Bachman, T Rochat

    Thorax
    |May 1, 1986
    PubMed
    Summary
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    This study investigated if endogenous opioids contribute to exercise-induced asthma. Results indicate that opioids are likely not involved in the development of exercise-induced asthma in patients.

    Area of Science:

    • Pulmonary Medicine
    • Exercise Physiology
    • Endocrinology

    Background:

    • Endogenous opioid peptides increase with exercise.
    • Opioids have been linked to specific asthma types in diabetic patients.
    • The role of opioids in exercise-induced asthma requires investigation.

    Purpose of the Study:

    • To determine if endogenous opioids mediate exercise-induced asthma.
    • To examine the relationship between exercise, opioids, and bronchoconstriction.

    Main Methods:

    • Measured plasma concentrations of beta endorphin, met-enkephalin, and adrenocorticotrophic hormone (ACTH) during exercise in asthmatic and normal subjects.
    • Administered naloxone infusion to asthmatic patients during exercise to assess its effect on FEV1.
    • Monitored FEV1 to evaluate bronchoconstriction in response to exercise and naloxone.

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    Main Results:

    • Exercise induced acute bronchoconstriction in all asthmatic participants.
    • No significant differences in plasma opioid peptide or ACTH levels were found between asthmatics and controls.
    • Naloxone infusion did not alter the severity of exercise-induced asthma.

    Conclusions:

    • Endogenous opioids do not appear to play a significant role in the pathogenesis of exercise-induced asthma.
    • The findings suggest alternative mechanisms underlying exercise-induced bronchoconstriction.