Deacetyl Mycoepoxydience Nanocrystals Dispersible Tablets Formulation and In Vitro Study

A novel nanocrystal dispersible tablets was developed by apply quality by design (QbD) approach in this study. Following Deacetyl Mycoepoxydience (DM) nanosuspensions was prepared by antisolvent precipitation approach; the DM nanocrystal was solidified by freeze-drying method. Following the screening of cryoprotectants for solidification of the nanosuspensions, the physicochemical properties including re-dispersability, mean particle size (MPS), morphology and dissolution behavior of the DM nanocrystal was investigated. Experiment was designed with focus on the types and quantities of disintegrating agent during the DM nanocrystal dispersible tablets preparation. The DM nanocrystal-loaded dispersible tablets were produced using direct powder compression. Judging form the tablet disintegration time, central composite design (CCD) and response surface methodology was adopted to optimize disintegrating agent. In conclusion, the nanocrystal dispersible tablets approach was a reliable method for improving the dissolution and thereby the oral bioavailability of the DM in formulation development.