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Updated: Feb 14, 2026

Isolation and Enrichment of Human Adipose-derived Stromal Cells for Enhanced Osteogenesis
Published on: January 12, 2015
Cytocompatibility and Osteogenesis of Adipose Tissue-Derived Stem Cells on POSS-PEG Coated Collagen
1Department of Fiber-System Engineering, Dankook University, 16890, Republic of Korea.
Abstract:
Nanostructured POSS-PEG nanoparticles (NPs, 42.4 nm ~) synthesized by formation of the urethane linkage between the monoisocyanate group (O═C═N-) of Polyhedral oligosilsesquioxane (POSS) macromers and the diol end groups (-OH) of polyethylene glycol (PEG) homopolymers as catalyzed by dibutyl tin dilaurate are of great interest for biomedical applications. However, NP materials based on nonorganic compounds can be cytotoxic. In this study, the preparation of PEG-POSS NPs followed the coating collagen assembly, which alleviates this problem. They also showed controlled surface properties in such a manner that hydrophobicity and biocompatibility were both reachable to give rise to improved cell viability. It indicates that the PEG-POSS coated collagen was appropriate for the proliferation of adipose tissue-derived stem cells to osteogenesis.
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