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Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
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Survival from alcoholic hepatitis has not improved over time
Emily Hughes1, Laurence J Hopkins2, Richard Parker2,3
1Leeds Liver Unit, St James's University Hospital, Leeds, United Kingdom.
Plos One
|February 15, 2018
Summary
Survival rates for alcoholic hepatitis (AH) have not improved despite advances in care. This study highlights the critical need for new treatments for this serious liver condition.
Area of Science:
- Hepatology
- Clinical Medicine
- Public Health
Background:
- Alcoholic hepatitis (AH) is a severe liver disease with high mortality.
- Understanding trends in AH survival is crucial for evaluating treatment efficacy and public health strategies.
Purpose of the Study:
- To analyze changes in survival rates for alcoholic hepatitis over time using published data.
- To identify any temporal trends in mortality associated with AH.
Main Methods:
- A systematic literature search was conducted across Embase and PubMed for studies on alcoholic hepatitis.
- Data from 77 studies (1971-2016) including 8,184 patients were analyzed for 28-day, 90-day, and 180-day mortality.
- Meta-regression analysis was used to adjust for confounding factors influencing mortality.
Main Results:
- Overall mortality rates for AH were 26% (28-day), 29% (90-day), and 44% (180-day).
- No significant changes in 28-day or 90-day mortality were observed over time.
- A slight increase in 180-day mortality was noted, but meta-regression revealed no overall temporal change in mortality after adjusting for other factors.
Conclusions:
- Mortality from alcoholic hepatitis has not improved over the study period (1971-2016).
- This lack of improvement is not attributable to changes in disease severity.
- There is an urgent unmet need for effective therapeutic interventions for alcoholic hepatitis.
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