Uterine artery embolization in a sheep model: biodegradable versus non-degradable microspheres

Area of Science:

• Interventional Radiology
• Vascular Surgery
• Gynecologic Oncology

Background:

• Transarterial embolization is a common treatment for various disorders.
• Permanent uterine artery occlusion can be disadvantageous.
• Comparing degradable and non-degradable microspheres is crucial for optimizing embolization outcomes.

Purpose of the Study:

• To compare local tissue effects and recanalization after uterine artery embolization using degradable starch microspheres (DSM) versus non-degradable tris-acryl microspheres (TGMS).
• To evaluate potential side effects associated with each type of microsphere.
• To assess the degree of recanalization in a sheep model.

Main Methods:

• Unilateral superselective uterine artery embolization in 22 female sheep.
• Use of degradable starch microspheres (Group A) or tris-acryl microspheres (Group B).
• Angiographic, gross, and histopathological evaluations were performed post-embolization.

Main Results:

• Successful embolization in all animals.
• Recanalization observed in 82% of sheep with DSM (Group A) versus 18% with TGMS (Group B).
• Similar tissue impairment in both groups, but more pronounced vascular changes with TGMS.

Conclusions:

• Embolization with DSM resulted in a significantly higher recanalization rate compared to TGMS.
• TGMS may lead to more pronounced vascular changes.
• The choice of microsphere impacts recanalization after uterine artery embolization.