An intrinsic suppressor cell-controlling formation of autologous rosettes in peripheral mouse lymphocytes

The existence of intrinsic suppressor cell-controlling autologous rosette formation in mouse peripheral blood lymphocytes was demonstrated. This cell is glass adherent, Thy 1,2 positive, and loses its activity after treatment with monoclonal anti-Lyt 2 antibodies plus complement. Suppression of the autologous rosette formation also involves a factor released by these cells directed against autologous erythrocytes. The suppressive phenomenon is strain specific.