Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

19.6K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.6K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

279
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
279
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

334
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
334
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

251
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
251
Bone Disorders01:29

Bone Disorders

5.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.5K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.3K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identifying Migraine Phenotype Post Traumatic Headache (MPTH) to Guide Overall Recovery From Traumatic Brain Injury.

Journal of child neurology·2022
Same author

Quality improvement in neurology: Headache Quality Measurement Set.

Neurology·2020
Same author

Practice guideline update summary: Pharmacologic treatment for pediatric migraine prevention: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society.

Headache·2019
Same author

New Guidelines: Interpretation, Application and the Future.

Headache·2019
Same author

Practice guideline update summary: Acute treatment of migraine in children and adolescents: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society.

Headache·2019
Same author

Practice guideline update summary: Pharmacologic treatment for pediatric migraine prevention: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society.

Neurology·2019
Same journal

Management of Menstrual Disorders in Adolescents of All Abilities.

Pediatric annals·2026
Same journal

The Intersection of Weight Management and Eating Disorders.

Pediatric annals·2026
Same journal

Recognizing and Responding to Complexity in the Medical Care of Adolescents.

Pediatric annals·2026
Same journal

Language Development in Bilingual Children: A Pediatrician's Guide.

Pediatric annals·2026
Same journal

Navigating Identification and Management of Substance Use in Adolescents.

Pediatric annals·2026
Same journal

Risks and Benefits of Social Media on Adolescent Health.

Pediatric annals·2026
See all related articles

Related Experiment Video

Updated: Feb 14, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.8K

Uncommon Pediatric Primary Headache Disorders.

M Cristina Victorio

    Pediatric Annals
    |February 16, 2018
    PubMed
    Summary
    This summary is machine-generated.

    Pediatric headache diagnoses include common migraine and tension-type headaches. This review covers rare primary headache disorders in children, aiding prompt diagnosis and treatment.

    More Related Videos

    A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
    07:01

    A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

    Published on: February 7, 2025

    918
    Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
    05:40

    Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

    Published on: July 29, 2021

    9.9K

    Related Experiment Videos

    Last Updated: Feb 14, 2026

    3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
    10:39

    3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

    Published on: June 2, 2014

    18.8K
    A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
    07:01

    A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

    Published on: February 7, 2025

    918
    Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
    05:40

    Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

    Published on: July 29, 2021

    9.9K

    Area of Science:

    • Pediatric Neurology
    • Headache Medicine

    Background:

    • Migraine and tension-type headaches are common in children and adolescents.
    • Unusual headaches can be alarming and perplexing for clinicians.
    • Some adult headache syndromes can manifest in childhood.

    Purpose of the Study:

    • To review uncommon primary headache disorders in pediatric patients.
    • To aid clinicians in identifying and managing these rare conditions.
    • To prevent unnecessary neurological consultations and treatment delays.

    Main Methods:

    • Literature review of primary headache disorders in children and adolescents.
    • Focus on conditions with unusual or peculiar features.
    • Discussion of clinical presentation and diagnostic considerations.

    Main Results:

    • Identified several uncommon primary headache disorders presenting in pediatric clinics.
    • Highlighted specific examples like brief stabbing headaches with lacrimation and continuous unilateral headaches.
    • Emphasized that these conditions, though more common in adults, can occur in children.

    Conclusions:

    • Awareness of uncommon primary headaches is crucial for pediatricians.
    • Accurate diagnosis can avert extensive neurological workups.
    • Timely recognition facilitates appropriate and specific therapeutic interventions.