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Generalized hyperhidrosis secondary to presumed eccrine gland dysfunction with possible apocrine metaplasia
Kumar Sukhdeo1, Jenna Beasley, Alisa Femia
1New York University Health, New York.
Dermatology Online Journal
|February 16, 2018
Summary
A 57-year-old man experienced generalized hyperhidrosis and skin papules. Histology revealed eccrine glands with an apocrine phenotype, suggesting metaplasia or apoeccrine glands.
Area of Science:
- Dermatology
- Histopathology
Background:
- Generalized hyperhidrosis can be a symptom of various underlying conditions.
- Skin manifestations like papules require thorough diagnostic investigation.
Observation:
- A 57-year-old male presented with excessive sweating and widespread, smooth, flesh-colored papules.
- Histological analysis of skin biopsies showed altered eccrine glands exhibiting an apocrine phenotype.
Findings:
- The observed histological changes suggest either apocrine metaplasia or the presence of apoeccrine glands.
- Morphological similarities and differences between eccrine, apocrine, and apoeccrine glands are discussed in relation to the patient's findings.
Implications:
- This case highlights the importance of considering glandular abnormalities in patients with hyperhidrosis and papular lesions.
- Further investigation into secondary causes of hyperhidrosis and ongoing management are crucial for patient care.
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