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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

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Pediatric head and neck squamous cell carcinoma: Patient demographics, treatment trends and outcomes

Ankit Modh1, Omar H Gayar2, Mohamed A Elshaikh1

  • 1Department of Radiation Oncology, Henry Ford Hospital, Detroit, MI, USA.

International Journal of Pediatric Otorhinolaryngology
|February 16, 2018
PubMed

Insights

Pediatric head and neck squamous cell carcinomas (SCC) are rare but require awareness. Laryngeal SCC shows significantly better survival than oral cavity or oropharyngeal SCC.

Area of Science:

  • Oncology
  • Pediatric Oncology
  • Head and Neck Surgery

Background:

  • Pediatric non-nasopharyngeal head and neck squamous cell carcinomas (HNSCC) are rare malignancies.
  • Understanding their epidemiology and treatment is crucial for early diagnosis and management.

Purpose of the Study:

  • To analyze patient demographics, temporal trends, treatment modalities, and survival outcomes for pediatric HNSCC.
  • To identify factors influencing survival in this rare pediatric cancer cohort.

Main Methods:

  • Utilized the National Cancer Database (NCDB) to identify pediatric patients (0-19 years) diagnosed with HNSCC between 2004 and 2013.
  • Analyzed data on patient demographics, tumor subsite, treatment regimens (surgery, radiation, chemotherapy), and overall survival.

Main Results:

  • A total of 159 pediatric HNSCC cases were identified, with oral cavity SCC being the most common (55%).
  • Incidence showed no significant change over the study period. Treatment varied by subsite, with trimodality for nasal cavity, chemoradiation for oropharynx, and surgery alone for oral cavity, larynx, and salivary glands.
  • The 5-year overall survival was 74%, with laryngeal SCC demonstrating significantly better survival (95%) compared to oral cavity (66%) and oropharyngeal SCC (68%).

Conclusions:

  • Pediatric non-nasopharyngeal HNSCC, though rare, necessitates consideration in the differential diagnosis of pediatric cancers.
  • Laryngeal SCC in children has a favorable prognosis compared to other head and neck subsites.
Abstract

Keywords:
Head and neck cancerNCDBPediatric cancerTreatment outcomesTrends

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