⁹⁰Y radioembolization dosimetry using a simple semi-quantitative method in intrahepatic cholangiocarcinoma: Glass...

There are two different types of ⁹⁰Y Microspheres, glass and resin, in the market for ⁹⁰Y radioembolization (⁹⁰Y-RE). This study aimed to investigate the dose of radiation delivered through glass vs. resin-based ⁹⁰Y-RE to intrahepatic cholangiocarcinoma (ICC).

In this retrospective study, 10 patients with ICC underwent ⁹⁰Y-RE, five underwent glass (Glass group) and other 5 resin (Resin group) microspheres. Technetium-99m macro-aggregated albumin (Tc-99m MAA) shunt study was performed two weeks before ⁹⁰Y-RE. Within 2 h from ⁹⁰Y-RE, Bremsstrahlung SPECT/CT was obtained. Regions of interest (ROIs) were segmented around the targeted tumor and the liver. Tumor and liver volumes, corresponding radioactive counts, and tumor to liver count ratio were calculated using MIM software and compared between Glass and Resin groups.

Mean hepatopulmonary shunt fraction was 7.1 vs. 6.2% for the Glass and Resin groups (p = 0.83), with no extrahepatic activity. There was no difference in the activity and tumor uptake of administered Tc-99m MAA between both groups (p = 0.71 and p = 0.63). Mean administered activity of ⁹⁰Y in the Glass group was higher than the Resin group (73.2 ± 24.3 vs. 44.5 ± 18.2 mCi, p < 0.001). The tumor ⁹⁰Y uptake was significantly higher in the Glass group compared to the Resin group (41.3% vs. 33.5%, p < 0.001), corresponding to the mean tumor dose of 205.7 ± 19.7 vs. 128.9 ± 10.6 Gy, respectively (p < 0.001). The tumor to normal liver parenchyma ⁹⁰Y dose ratio was significantly higher in the Glass group compared to the Resin group, 4.9 ± 0.7 versus 2.4 ± 0.3 respectably (p < 0.001).

Both ⁹⁰Y glass and resin-based microsphere ⁹⁰Y-RE are feasible and safe in patients with ICC, while ⁹⁰Y glass microsphere delivers higher dose of ⁹⁰Y to the targeted tumors.

While both ⁹⁰Y glass and resin-based microsphere yttrium-90 radioembolization are feasible and safe treatment options for in patients with intrahepatic cholangiocarcinoma, ⁹⁰Y glass microsphere delivers higher dose of ⁹⁰Y to the targeted tumors.

Both of ⁹⁰Y glass and resin-based microsphere can be safely and feasibly used for treatment of intrahepatic cholangiocarcinoma, difference in dose of ⁹⁰Y delivered to the targeted tumors should be clinically considered while choosing the microsphere type.