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Updated: Feb 14, 2026

Observation and Analysis of Blinking Surface-enhanced Raman Scattering
Published on: January 11, 2018
Injection molded lab-on-a-disc platform for screening of genetically modified E. coli using liquid-liquid extraction
Lidia Morelli1, Laura Serioli, Francesca Alessandra Centorbi
1Department of Micro- and Nanotechnology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark. lmor@nanotech.dtu.dk.
Abstract:
We present the development of an automated centrifugal microfluidic platform with integrated sample pre-treatment (filtration and liquid-liquid extraction) and detection (SERS-based sensing). The platform consists of eight calibration and four assay modules, fabricated with polypropylene using injection molding and bonded with ultrasonic welding. The platform was used for detection of a secondary bacterial metabolite (p-coumaric acid) from bacterial supernatant. The obtained extraction efficiency was comparable to values obtained in batch experiments and the SERS-based sensing showed a good correlation with HPLC analysis.
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