Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

3.0K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
3.0K
Protein Complex Assembly02:41

Protein Complex Assembly

16.9K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.9K
Complex Numbers01:29

Complex Numbers

344
The real number system cannot represent the square root of a negative number, which restricts solutions for certain equations, such as quadratics with negative discriminants. To address this, the complex number system was developed, introducing the imaginary unit i, where i = √(-1). This extension allows for the representation of all roots, including those involving negative radicands.A complex number is written in the form x + yi, where x and y are real numbers. Here, x represents the...
344
Formation of Complex Ions03:45

Formation of Complex Ions

26.3K
A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
26.3K
T Cell Types and Functions01:24

T Cell Types and Functions

2.7K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.7K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

3.3K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased Glucose Availability Sensitizes Pancreatic Cancer to Macrophage-Targeting Immunotherapies.

Cancer research communications·2026
Same author

MYC serine 62 phosphorylation promotes its association with DNA double-strand breaks to facilitate repair and cell survival under genotoxic stress.

Genes & development·2026
Same author

Impaired Adipose Anabolism in Pancreatic Cancer Cachexia Is Reversed by HuR Inhibition.

Journal of cachexia, sarcopenia and muscle·2026
Same author

Addressing pancreatic cancer disparities in Oregon's Native American population via tribally responsive research systems with the confederated tribes of warm springs.

Cancer causes & control : CCC·2026
Same author

Global mRNA 3'UTR lengthening in small-cell neuroendocrine carcinoma.

bioRxiv : the preprint server for biology·2026
Same author

A window trial in metastatic pancreatic ductal adenocarcinoma reveals resistance mechanisms to targeting the KRAS-MEK pathway.

bioRxiv : the preprint server for biology·2025
Same journal

Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications.

Wiley interdisciplinary reviews. RNA·2026
Same journal

Exploring New Frontiers in Bone Metabolism: Role and Potential of lncRNA DANCR.

Wiley interdisciplinary reviews. RNA·2026
Same journal

Functional Inclusion of RNA Biology in the Tethered Extracellular Matrix.

Wiley interdisciplinary reviews. RNA·2026
Same journal

Structural and Functional Diversity of RNA-Containing Toxin-Antitoxin Systems.

Wiley interdisciplinary reviews. RNA·2026
Same journal

Promoter-Targeting RNA Technologies: An Epigenetic Strategy for Gene Activation and Gene Silencing.

Wiley interdisciplinary reviews. RNA·2026
Same journal

LncRNA PCAT18: Roles and Mechanisms in Human Cancers.

Wiley interdisciplinary reviews. RNA·2026
See all related articles

Related Experiment Video

Updated: Feb 14, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

20.2K

Complex HuR function in pancreatic cancer cells.

Jonathan R Brody1,2, Dan A Dixon3

  • 1Division of Surgical Research, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.

Wiley Interdisciplinary Reviews. RNA
|February 17, 2018
PubMed
Summary
This summary is machine-generated.

Pancreatic cancer cells rely on the RNA-binding protein HuR (ELAVL1) for survival, especially in harsh tumor microenvironments. Targeting HuR offers a promising strategy to overcome therapeutic resistance in pancreatic ductal adenocarcinoma.

Keywords:
ELAVL1HuRRNA binding proteinspancreatic cancerpancreatic ductal adenocarcinoma

More Related Videos

Isolation of Stem Cells from Human Pancreatic Cancer Xenografts
11:44

Isolation of Stem Cells from Human Pancreatic Cancer Xenografts

Published on: September 26, 2010

22.9K
An Orthotopic Resectional Mouse Model of Pancreatic Cancer
07:17

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

Published on: September 24, 2020

12.6K

Related Experiment Videos

Last Updated: Feb 14, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

20.2K
Isolation of Stem Cells from Human Pancreatic Cancer Xenografts
11:44

Isolation of Stem Cells from Human Pancreatic Cancer Xenografts

Published on: September 26, 2010

22.9K
An Orthotopic Resectional Mouse Model of Pancreatic Cancer
07:17

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

Published on: September 24, 2020

12.6K

Area of Science:

  • Oncology
  • Molecular Biology
  • RNA Biology

Background:

  • Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with poor patient outcomes.
  • Known genetic drivers include KRAS, TP53, and SMAD4, but other resistance mechanisms remain understudied.
  • The tumor microenvironment presents challenges, including hypoxia and nutrient deprivation, fostering therapeutic resistance.

Purpose of the Study:

  • To investigate non-genetic targets contributing to PDAC cell survival and therapeutic resistance.
  • To highlight the role of RNA-binding protein HuR (ELAVL1) in PDAC biology.
  • To explore therapeutic strategies targeting HuR in PDAC.

Main Methods:

  • Review of existing research on PDAC genetics and tumor microenvironment.
  • Focus on posttranscriptional gene regulation mechanisms.
  • Analysis of the role of HuR (ELAVL1) in cancer cell survival.

Main Results:

  • HuR (ELAVL1) is a key regulator of posttranscriptional gene expression in PDAC.
  • Altered HuR activity supports a pro-survival phenotype in PDAC cells.
  • HuR's role is critical for PDAC cell survival within challenging tumor microenvironments.

Conclusions:

  • HuR (ELAVL1) is a crucial factor in PDAC cell survival and therapeutic resistance.
  • Targeting HuR represents a potential therapeutic avenue for PDAC treatment.
  • Further research into HuR-targeting strategies is warranted for PDAC.