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Accurate Follicle Enumeration in Adult Mouse Ovaries
Published on: October 16, 2020
Untapped Reserves: Controlling Primordial Follicle Growth Activation
Amanda Kallen1, Alex J Polotsky2, Joshua Johnson2
1Yale University School of Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Reproductive Endocrinology, New Haven, CT, USA.
Abstract:
Even with the benefit of assisted reproductive technologies (ART), many women are unable to conceive and deliver healthy offspring. One common cause of infertility is the inability to produce eggs capable of contributing to live birth. This can occur despite standard-of-care treatment to maximize the recovery of eggs from growing ovarian follicles. Dormant primordial follicles in the human ovary are a 'reserve ' that can be exploited clinically to overcome this problem. We discuss how controlling primordial follicle growth activation (PFGA) can produce increased numbers of high-quality eggs available for fertility treatment(s). We consider the state of the art in interventions used to control PFGA, and consider genetic and epigenetic strategies on the horizon that might improve compromised oocyte quality to increase live births.
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